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研究業績

学術論文

2024 

110) C. Kojima, J. Yao, K. Nakajima, M. Suzuki, A. Tsujimoto, Y. Kuge, M. Ogawa, A. Matsumoto, “Attenuated polyethylene glycol immunogenicity and overcoming accelerated blood clearance of a fully PEGylated dendrimer”, Int. J. Pharm., 659, 124193 (2024).

109) H. Shiba, T. Hirose, A. Sakai, I. Nakase, A. Matsumoto, C. Kojima, “Structural optimization of carboxy-terminal phenylalanine-modified dendrimers for T-cell association and model drug loading”, Pharmaceutics,  16, 715 (2024).

大阪公立大学での代表的な研究業績

106) C. Kojima, M. Sawada, I. Nakase, and A. Matsumoto, “Gene delivery into T Cells using ternary complexes of DNA, Lipofectamine, and carboxy-terminal phenylalanine-modified dendrimers”, Macromol. Biosci., 23, 2300139 (2023).
Selected as the cover image of Volume 23, Issue 141, published in November, 2023.

101)  H. Shiba, M. Nishio, M. Sawada, M. Tamaki, M. Michigami, S. Nakai, I. Nakase, I. Fujii, A. Matsumoto, C. Kojima, “Carboxy-terminal dendrimers with phenylalanine for pH-sensitive delivery system into immune cells including T cells”, J. Mater. Chem. B, 10, 2463-2470 (2022).
Selected as the cover image of Volume 10, Issue 14, published on April 14, 2022.

100)  C. Kojima, H. Xia, Y. Yamamoto, H. Shiigi, “A naked-eye colorimetric pH and temperature sensor based on gold nanoparticle-loaded stimuli-sensitive dendrimers”, ChemNanoMat, 8, e202100442 (2022). Selected as the cover image of Volume 8, Issue 3, published in March, 2022.

96) C. Kojima, T. Koda, T. Nariai, J. Ichihara, K. Sugiura, A. Matsumoto, “Application of zwitterionic polymer hydrogels to optical tissue clearing for 3D fluorescence imaging”, Macromol. Biosci.21, 2100170 (2021). 
Selected as the cover image of Volume 21, Issue 9, published on September 18, 2021.

95) A. Tsujimoto, H. Uehara, H. Yoshida, M. Nishio, K. Furuta, T. Inui, A. Matsumoto, S. Morita, M. Tanaka, C. Kojima, “Different hydration states and passive tumor targeting ability of polyethylene glycol-modified dendrimers with high and low PEG density”, Mater. Sci. Eng. C126, 112159 (2021).

89) R. Katayama, N. Tanaka, Y. Takagi, K. Shiraishi, Y. Tanaka, A. Matsumoto, C. Kojima, “Characterization of the hydration process of phospholipid-mimetic polymers using the air injection-mediated liquid exclusion methods”, Langmuir36, 5626-5632 (2020).

88) M. Tamaki, C. Kojima, “pH-Switchable LCST/UCST-type thermosensitive behaviors of phenylalanine-modified zwitterionic dendrimers”, RSC Advances10, 10452-10460 (2020).

87) Y. Nishimoto, S. Nagashima, K. Nakajima, T. Ohira, T. Sato, T. Izawa, J. Yamate, K. Higashikawa, Y. Kuge, M. Ogawa, C. Kojima, “Carboxyl-, sulfonyl-, and phosphate-terminal dendrimers as a nanoplatform with lymph node targeting”, Int. J. Pharm.576, 119021 (2020).

74) C. Kojima, Y. Nakajima, N. Oeda, T. Kawano, Y. Taki, “Visible laser-induced in situ cell detachment from gold nanoparticle-embedded collagen gel”, Macromol. Biosci.17, 1600341 (2017).

47) C. Kojima, Y. Watanabe, H. Hattori, T. Iida, “Design of photosensitive gold nanoparticles for biomedical applications based on self-consistent optical response theory”, J. Phys. Chem. C115, 19091-19095 (2011).

29) C. Kojima, S. Tsumura, A. Harada, K. Kono, “A collagen-mimic dendrimer capable of controlled release”, J. Am. Chem. Soc.131, 6052-6053 (2009).

1) C. Kojima, K. Kono, K. Maruyama, T. Takagishi, “Synthesis of polyamidoamine dendrimers having polyethylene glycol grafts and their ability to encapsulate anticancer drugs”, Bioconjugate Chem.11, 910-917 (2000). (2015年、25th anniversary collectionに選出。被引用回数400回以上)

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東京工業大学 物質理工学院 材料系

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Kojima Laboratory

Department of Materials Science and Engineering
Tokyo Institute of Technology

4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan

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